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Using estrogen alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using an estrogen product. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function).
Using estrogen alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots. Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.
The risks listed above are based on a study of an oral estrogen product, with and without a progestin. Since other products and doses have not been studied in the same way, it is not known how the use of Duavee, Estring, and Premarin Vaginal Cream will affect your chances of getting these conditions.
Do not take other progestin, estrogen, or estrogen agonist/antagonist products while taking Duavee or Prempro.
Estrogens with or without progestins should be used at the lowest dose possible, only for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment.
These are not all the risks for these products. Please see full Important Safety Information for more detail on this website.